• In 1998, he produced the film "Taken" with his friend, Ethan Embry. Another friend of Ethan's directed the film which has not yet been released.
• Mother is Reedy Gibbs
• Dated Reese Witherspoon
• Brother of Meadow Sisto.
• Jeremy's dad, Dick Sisto is a jazz DJ and musician in Louisville, Kentucky.
• Appears very young in the well-known Twisted Sister's video "We're not gonna take it".
• Recently formed his own production company, Dima Entertainment (April 2003)
• Played Jesus in the TV film Jesus, and a demon, in Hideaway.
• He grew up in Chicago, Illinois.
• Full name is Jeremy Merton Sisto. He was named after the trappist philosopher Thomas Merton.
• Raised as a youngster in a rock house built on 20 acres of land by his parents when they were farmers in the lower Sierra Nevada mountains. His parents divorced when he was six.
• At the age of 8 was living in Chicago and he and older sister Meadow began auditioning for theatre roles. The Goodman Theatre hired them both for a production of "House Not Meant to Stand." Another production "Galileo" in 1987 had Jeremy appearing with Brian Dennehy.
• Currently has a band and is working on getting an album out. He is the singer of the band and also plays guitar.
• Father Dick Sisto became a jazz musician and educator (his instrument is the vibes) who at one point was part of the Chicago jazz scene. He later hosted jazz shows on Louisville radio (WFPK); his mother Reedy Gibbs an actress.

Born and raised in Chicago, Jeremy Sisto began appearing in local theatre at the age of 11. By the time he was 16, he landed his first feature film, a starring role in Academy Award winner Lawrence Kasdan's Grand Canyon. Upon the completion of the film, Sisto returned to Chicago to finish high school and then relocated to Los Angeles in 1993 to pursue acting full-time.

He also starred opposite Alicia Silverstone in the 1995 summer hit, Clueless, as Elton, the hip man on campus. Sisto followed this with Moonlight & Valentino (1995), a heartfelt romantic comedy directed by David Anspaugh, in which he played Gwyneth Paltrow's love interest.

In 1998, Sisto worked opposite Billy Crudup in Without Limits, as Olympic athlete Frank Shorter. Sisto then starred in Artisan Entertainment's black comedy/thriller, Suicide Kings (1997) with Christopher Walken and Denis Leary, as a morphine-addicted medical student drawn into a plot to kidnap a local mobster.

Jeremy Sisto's flair for creating compelling yet charming characters attracted award-winning writer Alan Ball to create a role for Sisto on his HBO series, Six Feet Under. Sisto returns to the show for a fourth season as Billy Chenowith, the charismatic manic-depressive, whose unpredictable mood swings wreak havoc on his sister, played by Rachel Griffiths. During his last hiatus, he co-starred in the critically acclaimed stage play Take Me Out, in which he has garnered several nominations for prestigious theatre awards.